Search results for "Mutational fitness effects"

showing 2 items of 2 documents

Globally defining the effects of mutations in a picornavirus capsid

2021

The capsids of non-enveloped viruses are highly multimeric and multifunctional protein assemblies that play key roles in viral biology and pathogenesis. Despite their importance, a comprehensive understanding of how mutations affect viral fitness across different structural and functional attributes of the capsid is lacking. To address this limitation, we globally define the effects of mutations across the capsid of a human picornavirus. Using this resource, we identify structural and sequence determinants that accurately predict mutational fitness effects, refine evolutionary analyses, and define the sequence specificity of key capsid-encoded motifs. Furthermore, capitalizing on the derive…

PicornavirusViral proteinQH301-705.5Sciencevirusesmedicine.medical_treatmentPicornaviridaeComputational biologymedicine.disease_causeGenomeGeneral Biochemistry Genetics and Molecular BiologyVirusImmune systemcapsidmedicineSingle amino acidBiology (General)GeneTropismHost proteinGeneticsEvolutionary BiologyMicrobiology and Infectious DiseaseMutationmutational fitness effectsProteaseGeneral Immunology and MicrobiologybiologyGeneral NeuroscienceQRviral proteaseGeneral Medicinebiochemical phenomena metabolism and nutritionbiology.organism_classificationViruspicornavirusViral proteaseCapsidMutationMedicineCapsid ProteinsHuman genomeDeep mutational scanningResearch ArticleHuman
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The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus.

2004

6 pages, 3 figures.-- PMID: 15159545 [PubMed].-- PMCID: PMC420405.-- Supporting information (Table 3: Relevant information about each single-nucleotide substation mutant created) available at: http://www.pnas.org/content/101/22/8396/suppl/DC1

PopulationMutantMutagenesis (molecular biology technique)Evolutionary biologyVesicular stomatitis Indiana virusSingle-nucleotide substitutionsGenetic variationAnimalsPoint MutationMutational fitness effectseducationGeneticseducation.field_of_studyMultidisciplinarybiologyPoint mutationRNAGenetic VariationRNA virusRNA viral genomesBiological Sciencesbiology.organism_classificationBiological EvolutionGenetics PopulationVesicular stomatitis virusMutagenesis Site-DirectedProceedings of the National Academy of Sciences of the United States of America
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